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Preheat the Oven: Preheat your oven to 350°F (175°C).
Prepare the Mixture: In a large bowl, combine the cooked chicken, crumbled bacon, cooked pasta, broccoli, cream of chicken soup, sour cream, garlic powder, onion powder, salt, and pepper. Mix until well combined.
Add Cheese: Fold in half of the cheddar and mozzarella cheeses into the mixture.
Transfer to Dish: Pour the mixture into a greased 9×13 inch baking dish. Spread it out evenly.
Top with Cheese: Sprinkle the remaining cheddar and mozzarella cheese on top. If using, add breadcrumbs for a crunchy topping.
Bake: Bake in the preheated oven for 25-30 minutes, or until the cheese is bubbly and golden.
Serve: Let cool for a few minutes before serving. Enjoy your cheesy, comforting casserole!